Luda Diatchenko Selected Research

Catechol O-Methyltransferase (Methyltransferase, Catechol)

1/2016	Human Genetic Variability Contributes to Postoperative Morphine Consumption.
11/2014	Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain.
3/2014	Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision.
7/2012	Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients.
4/2012	Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity.
1/2011	Catechol O-methyltransferase haplotype predicts immediate musculoskeletal neck pain and psychological symptoms after motor vehicle collision.
4/2010	Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study.
1/2010	Assessing potential functionality of catechol-O-methyltransferase (COMT) polymorphisms associated with pain sensitivity and temporomandibular joint disorders.
1/2009	Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.
6/2007	Responses to Drs. Kim and Dionne regarding comments on Diatchenko, et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain 2006; 125: 216-24.

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Luda Diatchenko Research Topics

Disease

59	Pain (Aches) 11/2022 - 01/2005
16	Chronic Pain 11/2022 - 07/2006
11	Hypersensitivity (Allergy) 01/2022 - 01/2012
11	Hyperalgesia 07/2021 - 05/2006
7	Inflammation (Inflammations) 11/2022 - 12/2002
6	Neuralgia (Stump Neuralgia) 07/2021 - 01/2017
6	Musculoskeletal Pain 01/2017 - 07/2006
5	Temporomandibular Joint Disorders (Temporomandibular Joint Disorder) 12/2020 - 01/2010
4	Acute Pain 01/2022 - 01/2017
3	Neck Pain (Cervicalgia) 05/2019 - 01/2011
3	Low Back Pain (Lumbago) 12/2018 - 11/2006
3	Wounds and Injuries (Trauma) 01/2017 - 08/2013
2	Back Pain (Backache) 11/2022 - 09/2010
2	Facial Pain (Myofacial Pain) 01/2020 - 05/2019
2	Neuroblastoma 01/2017 - 12/2015
2	Osteoarthritis 11/2015 - 03/2012
1	Peripheral Nerve Injuries 11/2022
1	Fibromyalgia (Fibrositis) 12/2020
1	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 12/2020
1	Vulvar Vestibulitis 12/2020
1	Migraine Disorders (Migraine) 12/2020
1	Headache (Headaches) 05/2019
1	Medically Unexplained Symptoms 01/2019
1	Post-Concussion Syndrome 01/2017
1	Brain Concussion (Cerebral Concussion) 01/2017

Drug/Important Bio-Agent (IBA)

12	Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA 01/2016 - 12/2006
9	EnzymesIBA 01/2019 - 11/2006
8	Analgesics (Analgesic Drugs)IBA 11/2022 - 06/2010
8	Biological ProductsIBA 01/2022 - 01/2011
8	Opioid Analgesics (Opioids)IBA 01/2020 - 05/2006
6	Proteins (Proteins, Gene)FDA Link 11/2022 - 09/2010
6	Adrenergic Agents (Adrenergic Drugs)IBA 01/2017 - 07/2006
4	CalciumIBA 01/2022 - 01/2015
4	Capsaicin (Zostrix)FDA Link 01/2020 - 01/2012
4	Opioid Receptors (Opioid Receptor)IBA 10/2019 - 01/2014
4	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2017 - 07/2006
4	catechol (pyrocatechol)IBA 04/2012 - 06/2008
3	Pharmaceutical PreparationsIBA 11/2022 - 07/2018
3	Formaldehyde (Formol)FDA Link 01/2022 - 10/2015
3	Freund's AdjuvantIBA 01/2022 - 10/2017
3	Morphine (MS Contin)FDA LinkGeneric 01/2020 - 01/2016
3	Genetic Markers (Genetic Marker)IBA 01/2020 - 06/2013
3	LigandsIBA 01/2020 - 12/2015
3	CatecholaminesIBA 04/2016 - 01/2005
3	Propranolol (Inderal)FDA LinkGeneric 12/2015 - 04/2007
2	Peptides (Polypeptides)IBA 01/2022 - 03/2012
2	EpiregulinIBA 01/2020 - 09/2017
2	Biomarkers (Surrogate Marker)IBA 03/2019 - 12/2011
2	Serotonin (5 Hydroxytryptamine)IBA 01/2019 - 04/2012
2	MicroRNAs (MicroRNA)IBA 01/2017 - 01/2017
2	3' Untranslated Regions (3' UTR)IBA 01/2017 - 10/2015
2	MethyltransferasesIBA 04/2016 - 01/2005
2	Protein Isoforms (Isoforms)IBA 10/2015 - 11/2011
2	Voltage-Gated Sodium ChannelsIBA 12/2013 - 12/2007
2	DNA (Deoxyribonucleic Acid)IBA 08/2013 - 12/2002
2	CytokinesIBA 01/2012 - 12/2011
2	Adrenergic beta-Antagonists (beta-Adrenergic Blocking Agents)IBA 04/2010 - 04/2007
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 11/2022
1	RNA (Ribonucleic Acid)IBA 11/2022
1	SteroidsIBA 11/2022
1	ApolipoproteinsIBA 11/2022
1	Apolipoproteins E (ApoE)IBA 11/2022
1	SodiumIBA 01/2022
1	DCC ReceptorIBA 01/2022
1	Ketotifen (Ketotifene)FDA Link 07/2021
1	Mast Cell StabilizersIBA 07/2021
1	Mitochondrial DNA (mtDNA)IBA 12/2020
1	Monoclonal AntibodiesIBA 01/2020
1	AcetoneIBA 01/2020
1	Adenosine Triphosphate (ATP)IBA 01/2020
1	Type 1 Melanocortin ReceptorIBA 01/2020
1	Nortriptyline (Aventyl)FDA LinkGeneric 01/2020
1	ErbB Receptors (EGF Receptor)IBA 01/2020
1	Epidermal Growth Factor (EGF)IBA 01/2020
1	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 01/2020
1	GTP-Binding Proteins (G-Protein)IBA 10/2019
1	ORALIT (ORS)IBA 05/2019
1	Aromatic-L-Amino-Acid DecarboxylasesIBA 01/2019
1	Collagen Type II (Type II Collagen)IBA 01/2019
1	Antigen-Antibody Complex (Immune Complex)IBA 01/2019
1	AntibodiesIBA 01/2019
1	AntigensIBA 01/2019
1	Cartilage Oligomeric Matrix ProteinIBA 01/2019
1	AutoantibodiesIBA 01/2019
1	Interleukin-10 (Interleukin 10)IBA 01/2018
1	Nerve Growth Factor (NGF)IBA 01/2018
1	Gabapentin (Neurontin)FDA LinkGeneric 01/2017
1	HLA Antigens (Human Leukocyte Antigens)IBA 01/2017
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2017
1	Calcium Channels (Calcium Channel)IBA 01/2017
1	Heterogeneous-Nuclear Ribonucleoprotein Group C (HNRNP C Protein)IBA 02/2016
1	Long Noncoding RNAIBA 02/2016

Therapy/Procedure

5	Analgesia 10/2019 - 05/2015
4	Therapeutics 01/2021 - 04/2010
2	Mastectomy (Mammectomy) 03/2019 - 03/2012
2	Precision Medicine 01/2018 - 06/2013
2	Diskectomy (Discectomy) 03/2010 - 11/2006
1	Herniorrhaphy 03/2019
1	Anesthesia 07/2018
1	Ligation 01/2018